Perhaps the biggest difference I see between Buddhism and the world’s other largest religions (i.e., Christianity, Hinduism, and Islam) is whether or not they consider worldly life to be “good”.
The other big religions usually say that worldly life (i.e., mass production and consumption, seeking pleasure and avoiding pain, cultivating attachments to people and things, developing a sense of self, etc.) is good, is connected to an eternal creator God and is itself spiritually meaningful, is worth spending all of one’s time and energy exploring and pursuing, etc.
However, Buddhism says that we are in an unfortunate state of existence (involving constant struggle and inevitable loss), that the physical details of this life are ultimately meaningless because they are very fleeting, that the only God-like beings one can see from here are trapped in impermanent lives like we are (they only live longer than we do), and that one should spend as much time as possible trying to permanently (i.e., without rebirth) escape from this prison. From a Buddhist perspective, perhaps the only things in life that are really good are people’s capacities to help themselves and others understand and undo their predicament.